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Principles of early drug discovery - PubMed Central (PMC)

The output of a compound screen is typically termed a hit molecule, which has been demonstrated to have specific activity at the target protein. Screening hits form the basis of a lead optimization chemistry programme to increase potency of the chemical series at the primary drug target protein.

Chapter 3 Review Flashcards | Quizlet

Single-phase power is usually supplied to an industrial customer. ... A step-up transformer is one in which the secondary winding current is greater than the primary winding current. False. If the secondary circuit of a transformer becomes overloaded, the primary circuit will not be affected.

Use of Technology in Teaching and Learning | U.S ...

Technology ushers in fundamental structural changes that can be integral to achieving significant improvements in productivity. Used to support both teaching and learning, technology infuses classrooms with digital learning tools, such as computers and hand held devices; expands course offerings, experiences, and learning materials; supports learning 24 hours a day, 7 days a week; builds 21 st ...

2.3 Medical Waste Incineration

a port. An auxiliary burner is generally used to start combustion and maintain desired combustion temperatures. Both the primary and secondary chambers are usually lined with acid-resistant refractory brick, as shown in the schematic drawing, Figure 2.3-3. Volatiles and combustion gases pass from the primary chamber to the secondary chamber. The

primary election | Description, History, & Facts | …

A direct primary, which is now used in some form in all U.S. states, functions as a preliminary election whereby voters decide their party's candidates. In an indirect primary, voters elect delegates who choose the party's candidates at a nominating convention. Indirect primaries for the presidency of the United States are used …

Frequently Asked Questions about Shelf Offerings

immediate, continuous, or delayed primary offering by seasoned primary eligible issuers. How is a delayed primary offering typically conducted? In a delayed primary offering, the issuer typically will file a core or base prospectus as part of the initial filing of the registration statement. See "What is a 'base' or a 'core' prospectus?

Source documents definition — AccountingTools

They usually contain the following information: A description of a business transaction. The date of the transaction. A specific amount of money. An authorizing signature. Many source documents are also stamped to indicate an approval, or on which to write down the current date or the accounts to be used to record the underlying transaction.

What is Primary Storage? - Definition from WhatIs.com

Primary storage is the collective methods and technologies used to capture and retain digital information that is in active use and critical for an organization's operations. Primary storage data is frequently accessed by applications or other hardware systems and business users. In contrast, secondary storage is used for data that is less frequently accessed, or no longer accessed at all.

Acute Coronary Syndromes: Diagnosis and Management, Part I

Stability of Plaques and Tendency for Rupture. The stability of atherosclerotic plaques varies. Characteristics of so-called high-risk or vulnerable plaques include a large lipid core, thin fibrous caps, a high density of macrophages and T lymphocytes, 9,10 a relative paucity of smooth muscle cells, 11 locally increased expression of matrix metalloproteinases that degrade collagen, 12,13 ...

Primary vs. Secondary Storage: How do They Compare ...

You may be more familiar with primary storage as it is commonly used as random access memory (RAM), the memory used by computers for running programs and their data. Data saved within this type of storage is temporary and ephemeral. With secondary storage, it's that hard disk drive (HDD) in our computers.

What Are the Differences between Primary and Secondary ...

The major differences between primary and secondary storage are in how the central processing unit on a computer can access the storage and the way in which the storage is used.Primary storage typically refers to storage or memory directly connected to and accessed by a computer's CPU, and is typically volatile memory referred to as random access memory (RAM).

Deciduous teeth - Wikipedia

Deciduous teeth or primary teeth, also informally known as baby teeth, milk teeth, or temporary teeth, are the first set of teeth in the growth and development of humans and other diphyodonts, which include most mammals but not elephants, kangaroos, or manatees which are polyphyodonts.Deciduous teeth develop during the embryonic stage of development and erupt (break through the gums and become ...

Primary & Secondary tillage Implements and their uses

Primary & Secondary tillage Implements and their uses. Tillage is the manipulation of the soil into a desired condition by mechanical means; tools are employed to achieve some desired effect (such as pulverization, cutting, or movement). cultivator. agricultural technology: Fallow system and tillage techniques. cereal farming: Seedbed preparation.

Remote Sensors | Earthdata

Remote sensing instruments are of two primary types: Active sensors, provide their own source of energy to illuminate the objects they observe. An active sensor emits radiation in the direction of the target to be investigated. The sensor then detects and measures the radiation that is reflected or backscattered from the target.

Primary vs. Secondary - Primary Sources: A Research Guide ...

Primary Sources are immediate, first-hand accounts of a topic, from people who had a direct connection with it. Primary sources can include: Texts of laws and other original documents. Newspaper reports, by reporters who witnessed an event or who quote people who did.

What Is Mass Media? - Definition, Types, Influence ...

It is the primary means of communication used to reach the vast majority of the general public. ... The general public typically relies on the mass media to provide information regarding political ...

Primary Standards in Chemistry - ThoughtCo

Primary data is a type of data that is collected by researchers directly from main sources through interviews, surveys, experiments, etc. Primary data are usually collected from the source—where the data originally originates from and are regarded as the best kind of data in research. The sources of primary data are usually chosen and ...

Primary color - Simple English Wikipedia, the free ...

Primary colors (or primary colours) are sets of colors that can be combined to make a useful range of colors. The primary colors are those which cannot be created by mixing other colors in a given color space. For subtractive combination of colors, as in mixing of pigments or dyes for , the CMYK set of primaries is often used. In this system the primary colors are cyan, magenta,and yellow.

Primary and Secondary Resources - Research Process ...

Use primary resources to obtain a first-hand account to an actual event and identify original research done in a field. For many of your papers, use of primary resources will be a requirement. Original documents such as diaries, speeches, manuscripts, letters, interviews, records, eyewitness accounts, autobiographies.

Cell Culture Media: A Review - labome.com

Cell culture media generally comprise an appropriate source of energy and compounds which regulate the cell cycle. A typical culture medium is composed of a complement of amino acids, vitamins, inorganic salts, glucose, and serum as a source of growth factors, hormones, and attachment factors. In addition to nutrients, the medium also helps ...

3 Municipal Wastewater and Sludge Treatment

Now, primary treatment is used as an economical means for removing some contaminants prior to secondary treatment. The residue from primary treatment is a con-centrated suspension of particles in water called "primary sludge." Although the goal of primary wastewater treatment is to separate readily-removable suspended

Primary and secondary power distribution systems (layouts ...

Typically, a rural primary feeder supplies up to 50 distribution transformers, spread over a wide region but the figure significantly varies depending on configuration. They are sited on pole tops, cellars or designated small plots.

Primary sector of the economy - Economics Help

The primary sector is concerned with the extraction of raw materials. It includes fishing, farming and mining. In less developed economies, the primary sector will comprise the biggest part of the economy. Typically as an economy develops, increased labour productivity will enable workers to leave the agricultural sector and move to other ...

CHAPTER 3 PRIMARY TREATMENT - wefnet.org

However the depth of a primary tank is 17 usually somewhat greater than that of a secondary tank. This means secondary tanks are larger 18 and more spread out. The reason for this is that secondary tanks typically remove solids that are 19 much lighter in comparison to those removed by a primary tank. Therefore, a longer detention

Primary Election Versus General Election: Definition ...

This is the main election, held between the winners of the various primary elections. This election typically results in a much higher voter turnout than the primary elections.

Primary vs Secondary Sources | Explained with Easy Examples

A fictional movie is usually a primary source. A documentary can be either primary or secondary depending on the context. If you are directly analyzing some aspect of the movie itself – for example, the cinematography, narrative techniques, or social context – the movie is a primary source.

What is a Primary Storage Device? - Definition from Techopedia

Typically, primary storage devices have an instance of all the data and applications currently in use or being processed. The computer fetches and keeps the data and files it in the primary storage device until the process is completed or data is no longer required. Random access memory (RAM), graphic card memory and cache memory are common ...

Chapter 02: Electronic Flight Instruments

used to show rate of turn. Conventional symbology is used to depict heading and navigational information. DI 5100 FT A segmented triangle is used to show turn coordination. Figure 2-1. A typical primary flight display (PFD). Primary Flight Display (PFD) A PFD presents information about primary flight instruments,

What is Primary Data? + [Examples & Collection Methods]

Primary data is a type of data that is collected by researchers directly from main sources through interviews, surveys, experiments, etc. Primary data are usually collected from the source—where the data originally originates from and are regarded as the best kind of data in research. The sources of primary data are usually chosen and ...

All About Ignition System: Primary Circuit Of An Ignition ...

The primary circuit voltage is low, operating on the battery`s 12 volts. The wiring in this circuit is covered with a thin layer of insulation to prevent short circuits. Battery. To better understand the operation of the ignition system`s primary circuits, we will start at the battery …